The concentration of CO and duration of exposure.Ģ2. What are two factors of CO exposure that determines the patient’s toxicity? How does the CO-Hb complex dissociate after the removal from exposure?Ģ1. What mechanism of CO poisoning can cause reduced cardiac output and hypotension?ĬO binds to myoglobin in the heart and skeletal muscle.ġ5. This leads to impaired oxidative phosphorylation and causes the body to switch to anaerobic metabolism. What mechanism of CO poisoning can cause lactic acidosis?ĬO binds to cytochrome c oxidase in the mitochondria. The difference is that when it is only O2 binding, the affinity is not strong enough to prevent O2 from diffusing to hypoxic tissue.ġ3. This is similar to how when the 1st O2 binds to the site it makes it easier for other O2 molecules to bind. Oxygen’s affinity for the remaining 3 sites is dramatically increased (causing the O2 to stay bound and preventing it from diffusing into the tissues). What is the description of how the binding of CO at one of the oxygen sites affects oxygen’s affinity for the remaining three sites? What is the description of how the presence of CO-Hb affects oxyhemoglobin saturation?ĬO-Hb reduces oxyhemoglobin saturation and therefore reduces blood O2 carrying capacity.ġ2. The binding of each oxygen molecule makes it easier for the next to bind, (affinity increases with each oxygen molecule bound) so the curve has to be curved and it shifts in either direction.ġ1. Why does the oxyhemoglobin dissociation curve not form a straight line? Left shift: increased Hb-O2 affinity (O2 stays bound to Hb and cannot diffuse into the tissues) and right-shift: decreased Hb-O2 affinity (O2 has trouble staying bound to Hb and prefers to be in the tissues).ġ0. What does a left shift or a right shift on the oxyhemoglobin curve represent? How many oxygen binding sites are there for hemoglobin?ĩ. CO binds to cytochrome c oxidase in mitochondria and to myoglobin in heart/skeletal muscle.Ĩ. CO-Hb shifts the oxyhemoglobin dissociation curve to the left, thereby impairing the dissociation of O2 from hemoglobin, impairing O2 delivery to the tissues. Presence of CO-Hb reduces oxyhemoglobin saturation and decreases blood O2-carrying capacity. What are the three mechanisms of CO-induced hypoxia? Place the patient in a hyperbaric oxygen chamber.īinds to heme iron in hemoglobin with an affinity 250x that of O2, creating carboxyhemoglobin (CO-Hb) and causing tissue hypoxia.ħ. What is the most effective methods of treating carbon monoxide poisoning?
Smoke inhalation in fires, automobile exhaust fumes, faulty/poorly ventilated charcoal, kerosene, or gas stoves, and temporary use of electrical generators.ĥ. Give them 100% oxygen as soon as possible. As a Respiratory Therapist, in general, when patients are suspected of carbon monoxide poisoning, what is the first thing that must be done to treat this patient? What is an abbreviation for carbon monoxide?ģ. It is harmful and can be very dangerous if a person inhales too much of this gas.Ģ. Carbon Monoxide is a colorless, odorless, nonirritating gas produced by the incomplete combustion of any carbon-containing material.
0 kommentar(er)
